diff --git a/rtengine/CMakeLists.txt b/rtengine/CMakeLists.txt
index 0fab84b55..c657d6f9d 100644
--- a/rtengine/CMakeLists.txt
+++ b/rtengine/CMakeLists.txt
@@ -176,6 +176,18 @@ if(LENSFUN_HAS_LOAD_DIRECTORY)
     set_source_files_properties(rtlensfun.cc PROPERTIES COMPILE_DEFINITIONS RT_LENSFUN_HAS_LOAD_DIRECTORY)
 endif()
 
+if(CMAKE_CXX_COMPILER_ID STREQUAL "GNU" AND CMAKE_CXX_COMPILER_VERSION VERSION_GREATER_EQUAL "12.0")
+    # procparams.cc takes a long time to compile with optimizations starting
+    # with GCC 12.1 due to PTA (see issue #6548)
+    get_source_file_property(PROCPARAMS_COMPILE_OPTIONS procparams.cc COMPILE_OPTIONS)
+    if(PROCPARAMS_COMPILE_OPTIONS STREQUAL "NOTFOUND")
+        set(PROCPARAMS_COMPILE_OPTIONS "")
+    else()
+        set(PROCPARAMS_COMPILE_OPTIONS "${PROCPARAMS_COMPILE_OPTIONS};")
+    endif()
+    set(PROCPARAMS_COMPILE_OPTIONS "${PROCPARAMS_COMPILE_OPTIONS}-fno-tree-pta")
+    set_source_files_properties(procparams.cc PROPERTIES COMPILE_OPTIONS ${PROCPARAMS_COMPILE_OPTIONS})
+endif()
 
 if(WITH_BENCHMARK)
     add_definitions(-DBENCHMARK)